Prednisone generic is a synthetic corticosteroid agent or drug used to treat a number of inflammatory conditions in the body. As everyone knows that the human body has its own defense system known as the immune system. It protects the body against harmful organisms like bacteria and disease. Sometimes the immune system become hyperactive and starts producing hyper immune responses. These hyper responses starts damaging tissues of the body and produce massive inflammation. That’s when Prednisone generic comes in handy. It is used for treatment of a number of hypersensitivity reactions, allergies and some types of cancers. Its use is indicated in asthma, chronic obstructive pulmonary disease (COPD), arthritis, Crohn’s disease, ulcerative colitis, adrenocortical insufficiency, tuberculosis, urticaria, nephritic syndrome, pericarditis, myasthenia gravis and transplant rejection.
Prednisone generic is also used for the treatment of migraine headaches and cluster headaches and some cancers including Hodgkin’s lymphoma, non Hodgkin’s lymphoma, acute lymphoblastic leukemia and multiple myeloma.
Prednisone generic has a good oral bioavailability; it means that it is well absorbed into our blood stream after taking it orally in the form of a tablet. After absorption into our blood system it does not immediately starts functioning but has to be converted into another activated compound to do so. That happens in our liver. The blood from the gastrointestinal system goes directly to liver before going to any other organ of the body. The liver has some enzymes that convert prednisone into its activated form called prednisolone. This process is known as the first pass metabolism.
After activation the drug ( Prednisone generic ) then goes to the rest of the body in blood and performs its action. It does so by binding to glucocorticoid receptors, which are specialized protein molecules. These are present inside almost all cell of our body. Activated Prednisone generic has high affinity for alpha and beta type of these glucocorticoid receptors. After binding to these receptors a drug-receptor complex is formed. This complex then acts on the DNA of our cells, which is present inside the nucleus and has a major role in protein synthesis. Thus Prednisone generic actually alters or affects the protein synthesis. Proteins are the biochemical machinery of our body. They help carry out various functions. By affecting their synthesis, a number of processes taking place in our body can be altered.
The activated form of Prednisone generic, the prednisolone is also available in the market but it is mostly used for topical administration e.g. in eye drops because that route does not involve liver and so the drug needs to be pre activated before use. However prednisone generic (Deltasone) the tablet form of Prednisone generic is available in 10 mg and 20 mg form. It is relatively safe and depends on liver for activation inside the body. Other brands are also available.
Although Prednisone generic is a relatively safer drug, but like most of the other drugs it has some adverse effects which includes, Increased glucose level in blood so it should be used cautiously in diabetics, fluid retention, insomnia mood disorders, and euphoria.