The Difference Between Prednisone Generic And Prednisolone

Some people might be confused about the difference between prednisone generic (Deltasone) and prednisolone generic (Delta-Cortef). Even though prednisolone and prednisone generic are both effective and they are both used in the same way, they are not the same and their application must not be confused with each other.

Prednisone generic (Deltasone) and prednisolone (Delta-Cortef) are both classified as Corticosteroid drugs. They are both synthetic members of the class of hormones called glucocorticoids. Both of them are synthetic (man-made) steroids that are used to hold back immune responses and reduce inflammation. Most glucocorticoids are synthetic analogues of hormones secreted by the zona fasciculata of the adrenal cortex. The adrenal cortex is located along the restriction of the Adrenal gland that is found on the top of the kidneys. Glucocorticoids exert metabolic, immunosuppressant and anti-inflammatory effects to our body.

The main active ingredients in all types of glucocorticoid drugs are the prednisone generic, that’s why it is the most widely used and the most prescribed glucocorticoid drug by doctors. Prednisone generic is activated by the enzymes in the liver and then transformed into prednisolone. Prednisone generic is also the precursor of prednisolone. Prednisone generic is just a prednisolone having an 11-keto instead of having an 11-beta-hydroxy group. Both prednisone generic (Deltasone) and prednisolone (Delta-Cortef) works by suppressing immune responses and hypersensitivity through a process not entirely understood. Scientists think that this hormone decrease these responses by preventing and suppressing cell-mediated immune reactions; reducing the concentration of thymus-dependent leukocytes, eosinophils, and monocytes; lessening the fastening of immune-globulin to cell surface receptors; and inhibits inter-leukin synthesis. Also, prednisone generic and prednisolone suppresses the edema, heat, tenderness, and redness associated with inflammatory responses.

Prednisone generic and prednisolone have also the same side effects, prolonged therapy with these dugs causes abnormal fat distribution, depleting it in the extremities and increasing its deposition in the face, abdomen, and between the shoulder blades. It can lead also to Cushing’s syndrome, a kind of disease involving the adrenal glands. Prednisone generic and prednisolone can also cause protein destruction or catabolism and inhibited protein synthesis, which results to muscle wasting, weakness, osteoporosis, poor wound healing, and immune-suppression. Prednisone generic and prednisolone also alters carbohydrate metabolism by promoting glyconeogenesis and glycogenolysis and by antagonizing the action of insulin. This can result in diabetes mellitus in susceptible people. It may also cause hyperglycemia, glycosuria, and an increase in the severity of existing diabetes mellitus.

Prednisolone is easily absorbed by the body that’s why it is the drug of choice for hepatic disease. The usual dosage of prednisolone for adults is initially 5 to 60 mg P.O daily in two to four doses and further therapy must be individualized for each patient; while the usual dosage of prednisone generic for adults is 5 to 60 mg P.O. daily and further therapy must also be individualized for each patient. Only a physician or a healthcare professional could decide whether a patient should take in prednisone generic or prednisolone which also depends on the patient’s health condition.